Impact of low birthweight on intergenerational growth of the offspring in model mouse. Mus musculus strain:ICR

Low birthweight (LBW) is associated with an elevated risk of adult-onset diseases, including kidney diseases, and affects subsequent generations. However, the underlying mechanism driving these intergenerational impacts remains poorly understood. In this study, we established an animal model of LBW induced by reduced uterine perfusion pressure (RUPP) procedure that recapitulates the phenotype of LBW. The study compared the two groups of pups: those born from the sham group and the RUPP group. We analyzed metabolites in the organs (liver and placenta) of the animal model using GC-MS/MS TQ8040 (Shimadzu). The retention times indicated in the Smart Metabolites Database (Shimadzu) were used as references to create a library for data analysis. From the results, we identified relevant pathologies in adulthood and subsequent generations based on metabolic changes in the organs affected by LBW.