List of new drug-target interactions predicted by interaction profile similarity and confirmed by experimental kinase activity assay.

Enzyme activity was measured at a compound concentration of 1μM and 10μM. Drugs able to lower the enzyme activity to less than 50% (above dashed line) at 10μM were defined as strong inhibitors while drugs that lowered kinase activity at 10μM between 50% and 70% (below dashed line) were classified as weak inhibitors. Discarding the disinfectant Hexachlorophene because of its low medical interest, two compounds have been highlighted for showing inhibition at both 1μM and 10μM, ibrutinib and suramin.