Ameliorative effect of roxithromycin against prostate inflammation-induced chronic pelvic pain in a preclinical model

In view of the well-known anti-inflammatory property of roxithromycin, the present study was carried out to evaluate its efficacy in ameliorating prostate inflammation-induced chronic pelvic pain in a rat model. Inflammation was induced by a single intra-prostatic injection of carrageenan, where a time course study revealed a peak histology score on day 14. The efficacy study was carried out in four sets of rats, each comprising 5 groups, which included the respective normal and experimental controls (NC, EC). The drugs (roxithromycin 5 and 20 mg/kg, diclofenac 5 mg/kg) were given daily orally, and pain score and body weight were evaluated at different time intervals. The prostatic index, vascular permeability, tissue levels of TNF-α and PGE2, thiobarbituric acid reactive substances, glutathione and superoxide dismutase, histology score, and immunoreactivity of COX-2 and iNOS were evaluated on day 14. Like diclofenac, roxithromycin decreased pain scores, and the rats gained weight ..., , # Open Source Data

We have submitted our raw data. Time_course study (**Time_Course.csv**), Body weight and prostatic index (**BW_and_PI.csv**), Evans blue dye extraction (**EBD.csv**), Oxidative marker GSH (**GSH.csv**), Histology score (**Histology_score.csv**), Immunoreactivity score (**IR_SCORE.csv**), Pain_score (**Pain_Score.csv**), Inflammatory marker PGE2 (**PGE2.csv**) Oxidative marker SOD (**SOD.csv**) Oxidative marker TBARS (**TBARS.csv**), Inflammatory marker TNF-α (**TNF-α.csv**)

## Descriptions

### Time_course study

```
* Day 0 - Histology score of rats sacrificed on day 0
* Day 7 - Histology score of rats sacrificed on day 7
* Day 14 - Histology score of rats sacrificed on day 14
* Day 21 - Histology score of rats sacrificed on day 21

* n = sample number used for the calculation
* Mean & SEM = Standard Error of mean
```

### BW_and_PI

* *NC*: Normal control - No intervention is done
* *EC*: Experimental control - Intra- prostastic injection of carrageenan given
* *R...,