GECKO sequencing

NIAID Data Ecosystem2026-05-01 收录

CRISPRi筛选

药物靶点发现

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP408642 数据链接链接失效反馈

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资源简介：

Goal of this study is to analyze gene enrichment comparing samples of treated (Brigatinib or Ceritinib, 300nM and 750nM respectively) versus untreated (DMSO)

创建时间：

2024-02-14

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis [TargetedCRISPRscreen]

白血病发病机制

CRISPRi筛选

Investigating Bcor target genes in BcorΔE9-10KrasG12D leukaemia with a custom CRISPR dropout screen BcorΔE9-10KrasG12D cell line was transduced with a custom CRISPR library and a dropout screen was pe

NIAID Data Ecosystem30

Identification of Aryl Hydrocarbon Receptor (AhR) as a Functional Target that Enhances Astrocytic ApoE Secretion

药物靶点发现

阿尔茨海默病研究

We discovered a chemical series that enhances ApoE secretion from human astrocytes through mechanisms independent of LXR agonism. Using chemoproteomics, photoaffinity probes, KINOMEscan analysis, and

NIAID Data Ecosystem00

RNA-sequencing and CRISPR/Cas9 Screen of PEO1 cells grown in suspension.

CRISPRi筛选

失巢凋亡逃逸

RNA-sequencing of PEO1 cells grown in suspension (SUS1 and SUS3) was performed to evaluate transcriptional reprogramming during anokis escape. CRISPR/Cas9 screen of PEO1 cells grown in adherent and su

NIAID Data Ecosystem00

Genes we prioritised as drug targets that had MR and colocalization evidence with other indications.

药物靶点发现

基因-疾病关联

Gene expression-disease relationship identified in the main MR (instrument-gene-indication): Alzheimer’s disease (AD), Schizophrenia (Sz), anorexia (AN), suggested direction of drug action according t

Figshare2021-01-08 更新00

PanDDA analysis group deposition -- SARS-CoV-2 Nsp1 crystal Apo12 (dataset 1) from the KIT library screening campaign, data used for ground state calculation

SARS-CoV-2Nsp1结构分析

药物靶点发现

PanDDA analysis group deposition -- SARS-CoV-2 Nsp1 crystal Apo12 (dataset 1) from the KIT library screening campaign, data used for ground state calculation

NIAID Data Ecosystem00

GECKO sequencing

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