Phlorizin Prolongs the Lifespan of Caenorhabditis elegans by Insulin and SIR-2.1 Regulation

Phlorizin
has significant antioxidant properties and was studied
using Caenorhabditis elegans to explore
potential antiaging mechanisms. Results showed that phlorizin mitigated
the harmful effects of high temperatures and hydrogen peroxide, reduced
oxidative stress, increased antioxidant enzyme activity, and reduced
malondialdehyde levels. Network pharmacological analysis reveals that
the AKT1, INSR, and SOD2 signaling pathways play a key role in the
antiaging effects of phlorizin. Its action is mediated by insulin
and SIR-2.1, influencing DAF-16, SKN-1, and downstream genes in the
antiaging effects. This implicates phlorizin as a promising functional
food additive targeting the DAF-16 and SOD-3 axes for antiaging.