DEMETER 2 Combined RNAi

Cancer cell line genetic dependencies estimated using the DEMETER2 model. DEMETER2 is applied to the combination of three large-scale RNAi screening datasets: the Broad Institute Project Achilles, Novartis Project DRIVE, and the Marcotte et al. breast cell line dataset. This dataset is derived from https://doi.org/10.6084/m9.figshare.6025238.v4 and formatted to more closely match quarterly releases. Specifically, the main matrices have been transposed so that they are indexed by cell line, cell lines are identified by DepMap IDs, and common dependencies and dependency probability estimated. Only select files are included. Refer to the original dataset for all files. See README for more information about files.
Visit the Cancer Dependency Map portal at https://depmap.org to explore related datasets. Email questions to [e-mail]