Crystal structure of VIM-2 in complex with triazole-based inhibitor OP24

Crystal structure of VIM-2 in complex with triazole-based inhibitor OP24 Descriptor: 5-(4-chloranyl-1,5-dimethyl-pyrazol-3-yl)-4-ethyl-1,2,4-triazole-3-thiol, FORMIC ACID, Vim-1, ... Authors: Maso, L, Spirakis, F, Santucci, M, Simon, C, Docquier, J.D, Cruciani, G, Costi, M.P, Tondi, D, Cendron, L. Deposit date: 2019-11-15 Release date: 2020-10-14 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Virtual screening identifies broad-spectrum beta-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases. Sci Rep, 10, 2020VIM-2与三唑类抑制剂（triazole-based inhibitor）OP24结合的晶体结构 组分描述：5-(4-氯-1,5-二甲基-吡唑-3-基)-4-乙基-1,2,4-三唑-3-硫醇、甲酸、Vim-1…… 作者：Maso L、Spirakis F、Santucci M、Simon C、Docquier J.D.、Cruciani G、Costi M.P.、Tondi D、Cendron L. 提交日期：2019-11-15 发布日期：2020-10-14 最后更新日期：2024-01-24 检测方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.6埃 引用文献：虚拟筛选发现可靶向临床相关丝氨酸型与金属型碳青霉烯酶（serine- and metallo-carbapenemases）的广谱β-内酰胺酶（beta-lactamase）抑制剂，《科学报告（Sci Rep）》，第10卷，2020年