Objective: Due to the initiation of the priority review program in China, many antitumor drugs have been approved for marketing based on phase II clinical trials and short-term surrogate endpoint indi
Background Individual-level surrogacy (ILS) assesses how well a surrogate endpoint predicts treatment effect at the individual level. The paper discusses mutual information (MI) and the likelihood red
PurposeTo investigate whether progression-free survival (PFS) or time to progression (TTP) could be a valid surrogate endpoint for overall survival (OS) in patients with limited-stage small-cell lung