The estimate differences in scores between the no migraine group and the migraine groups at the two-year follow-up.a.b,c,d

HAMD = Hamilton Depression Rating Scale, DS = Depression subscale of the Depression and Somatic Symptoms Scale (DSSS), SS = Somatic subscale of the DSSS, HADS-D = Depression subscale of the Hospital Anxiety and Depression Scale (HADS), HADS-A = Anxiety subscale of the HADS*p ** p a The no migraine subgroup was used as a reference.b Patients without migraine at baseline were categorized as the no migraine group. Patients with migraine diagnosed at baseline and with no headache or mild headache at follow-up were categorized as the inactive migraine group. Patients with migraine diagnosed at baseline and with moderate or severe headache at follow-up were categorized as the active migraine group.c Subjects with pharmacotherapy in the index follow-up month were categorized as the treated group and those without pharmacotherapy were categorized as the undertreated group.d The estimate difference was calculated by general linear models and represented the differences in scores between two groups after controlling for demographic variables.The estimate differences in scores between the no migraine group and the migraine groups at the two-year follow-up.a.b,c,d