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Cryo-EM structure of the mRNA translating and degrading yeast 80S ribosome-Xrn1 nuclease complex

NIAID Data Ecosystem2026-05-10 收录

核糖体-核酸酶复合物结构

RNA降解机制

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https://www.rcsb.org/structure/6Q8Y 数据链接链接失效反馈

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Cryo-EM structure of the mRNA translating and degrading yeast 80S ribosome-Xrn1 nuclease complex

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创建时间：

2025-12-17

RNA质量控制

RNA降解机制

Mutations in the 3’-5’ exonuclease DIS3L2 are associated with Perlman syndrome and hypersusceptibility to Wilms’ tumorigenesis. Previously, we found that Dis3l2 specifically recognizes and degrades ur

NIAID Data Ecosystem70

Transcriptome Wide Annotation of Eukaryotic RNase III Reactivity and Degradation Signals [ncRNA-Seq]

RNA降解机制

转录组稳定性

Here we present complete genomic and biochemical annotations of the signals required for RNA degradation by the dsRNA specific ribonuclease III (Rnt1p) and examine its impact on transcriptome stabilit

NIAID Data Ecosystem40

ExtFig4A_RACE_D108A_R3_LG320_annotated.tif

RNA降解机制

"5RACE转录本鉴定"

HEK293T ishXrn1 cells were treated with doxycycline for 3-4 days to induce knock down of Xrn1, then transfected with the luciferase reporters containing 99 bp insertions from the STOML2, and where ind

NIAID Data Ecosystem40

Fig2F_STOML2_ExtFig4C_BCAP31_RACE_R2_LG297_annotated.tif

病毒-宿主相互作用

RNA降解机制

HEK293T ishXrn1 cells were treated with doxycycline for 3-4 days to induce knock down of Xrn1, then transfected with PA-X from the influenza A/Puerto Rico/8/1984 (H1N1) ("PR8") or A/Perth/16/2009 (H3N

NIAID Data Ecosystem40

Mammalian microRNAs predominantly act to decrease target mRNA levels

miRNA靶基因调控

RNA降解机制

MicroRNAs (miRNAs) are endogenous ~22-nucleotide RNAs that mediate important gene-regulatory events by pairing to the mRNAs of protein-coding genes to direct their repression. Repression of these regu

NIAID Data Ecosystem40

Cryo-EM structure of the mRNA translating and degrading yeast 80S ribosome-Xrn1 nuclease complex

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