Crystal Structure of Human Beta Secretase in Complex with compound 12a
收藏Protein Data Bank Japan2024-10-30 更新2026-03-21 收录
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Crystal Structure of Human Beta Secretase in Complex with compound 12a Descriptor: (1S,3S,4S,5R)-3-{4-amino-3-fluoro-5-[(1,1,1,3,3,3-hexafluoropropan-2-yl)oxy]benzyl}-5-[(3-tert-butylbenzyl)amino]tetrahydro-2H-thiopyran-4-ol 1-oxide, Beta-secretase 1 Authors: Rondeau, J.M, Bourgier, E. Deposit date: 2013-07-30 Release date: 2013-08-28 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides. Bioorg.Med.Chem.Lett., 23, 2013
创建时间：
2013-07-30
