Delivery System for RNA based Therapy of Cardiovascular Diseases A Systematic Review (Data).xlsx

This dataset comprises detailed information extracted from a systematic review of 18 studies that investigated RNA-based therapies for various cardiovascular diseases using murine models. The reviewed cardiovascular conditions include myocardial infarction, cardiomyopathy, systemic hypertension, atherosclerosis, coronary heart disease, heart failure, myocarditis, and endothelial dysfunction. The dataset highlights the following key aspects:<b>RNA Delivery Methods:</b> The studies explored different RNA delivery systems, including viral vectors, lipid nanoparticles, and polymer nanoparticles.<b>Administration Routes:</b> The primary routes of administration were direct tissue injection and intravenous injection.<b>Impact on RNA Levels:</b> Changes in RNA levels post-therapy were reported in 15 studies, with varying impacts depending on the delivery vehicle used.<b>Effects on Target Proteins:</b> Thirteen studies documented the effects on specific target proteins.<b>Clinical Outcomes:</b> Seventeen studies reported achieving desired clinical outcomes following the induction of RNA therapy.