Highly Enantioselective Copper-Catalyzed Electrophilic Trifluoromethylation of β-Ketoesters
收藏Figshare2016-02-20 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Highly_Enantioselective_Copper_Catalyzed_Electrophilic_Trifluoromethylation_of_Ketoesters/2508388
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资源简介：
Enantioselective Cu-catalyzed trifluoromethylation of β-ketoesters using commercially available trifluoromethylating reagents is reported. A number of α-CF3 β-ketoesters are obtained with up to 99% ee. The trifluoromethylated products were then transformed diastereoselectively to α-CF3 β-hydroxyesters with two adjacent quaternary stereocenters via a Grignard reaction.
创建时间：
2016-02-20
