Crystal Structure of small molecule beta-lactone 5 covalently bound to K-Ras(G12S)
收藏Protein Data Bank Japan2024-10-09 更新2026-04-19 收录
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Crystal Structure of small molecule beta-lactone 5 covalently bound to K-Ras(G12S) Descriptor: (3R,4R)-1-[7-(8-chloronaphthalen-1-yl)-8-fluoro-2-{[(4S,7as)-tetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-4-yl]-3-hydroxypiperidine-4-carbaldehyde, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Ziyang, Z, Guiley, K.Z, Shokat, K.M. Deposit date: 2022-01-18 Release date: 2022-08-03 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.80000720583 Å) Cite: Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S). Nat.Chem.Biol., 18, 2022
创建时间：
2022-01-18
