List of UniProt feature "domain" (n = 124) that overlap with disordered regions (IDRs) of 105 intrinsically disordered proteins.

For each domain, the table lists the UniProt feature description (UniProt feature: domain), UniProt identifier, gene name, DisProt identifier for the protein, start/end of the disordered regions that overlap with the domain, categories of IDRs in terms of their function, interaction partners, structural state, and structural transitions (DisProt annotation). Additionally, we report whether a UniProt-annotated domain is present in the Disordered Binding Sites (DIBS) and the Mutual Folding Induced by Binding (MFIB) databases. When a domain is present in these databases, we report the accession of the corresponding entry in the database and the PDB ID reported in these databases, as a form of evidence. 30 out of 124 UniProt-annotated domains have been determined to have the “disorder” structural state and undergo “disorder to order” structural transition, according to DisProt (highlighted in orange). Eleven UniProt-annotated domains, overlapping with IDRs, were also annotated in DIBS and MIFB databases, highlighted in green and yellow, respectively, to being unstructured in isolation but forming structures only upon binding. (XLSX)