Chemical speciation of 3d metals in amyloid plaques
收藏DataCite Commons2026-02-02 更新2026-05-03 收录
下载链接：
https://doi.esrf.fr/10.15151/ESRF-ES-2301224132
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资源简介：
Alzheimer’s Disease (AD) is characterized by amyloid-β (Aβ) plaques and oxidative stress linked to Fe, Cu, and Zn accumulation. Using μ-XANES at ESRF ID21, we will map these metals’ oxidation states in APP23 mouse brain slices, correlating them with histological data. This will reveal metal-Aβ interactions, clarifying their role in plaque formation and neurotoxicity. By validating theoretical coordination models, our study will provide crucial insights into metal-driven oxidative stress in AD, bridging structural and pathological mechanisms. Findings will contribute to understanding neurodegeneration, aiding the development of targeted therapeutic strategies
提供机构：
European Synchrotron Radiation Facility
创建时间：
2026-02-02
