Data associated with the publication: High mannose content of mesenchymal glioblastoma correlates with Hydroxyl Proton Transfer–weighted (HPTw) MRI as a noninvasive biomarker of tumor aggressiveness

<p>This dataset supports the study <i>"High mannose content of mesenchymal glioblastoma correlates with Hydroxyl Proton Transfer–weighted (HPTw) MRI as a noninvasive biomarker for tumor aggressiveness.”</i> It centers on imaging N-linked mannosylation in glioblastoma (GBM) cells and its relationship to tumor aggressiveness. The dataset contains four components:</p>
<ol>
<li>GBM cell/target characterization – Transcriptomic analyses, histopathological staining (35 GBM cases), qRT-PCR, Western blotting, functional assays of mannosylation-related genes.</li>
<li>In vitro data –MRI, immunohistology, and biochemical profiling of GBM cell lines.</li>
<li>In vivo data – MRI of aggressive vs. less aggressive GBM tumors in mice mode.</li>
<li>Ex vivo data - Immunohistopathology</li>
</ol>
<p>The data demonstrate that elevated mannose levels, detectable by MANw CEST MRI, are associated with mesenchymal GBM cells and can serve as a surrogate imaging biomarker of tumor aggressiveness and recurrence.</p>