Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates
收藏NIAID Data Ecosystem2026-04-25 收录
下载链接：
https://www.ncbi.nlm.nih.gov/sra/SRP200062
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资源简介：
We engineered m6A methyltransferase or demethylases with CRISPR-Cas9 to achieve site-specific editing of m6A. The resultant m6A editors can be programmed with a guide RNA, allowing functional comparison of single site methylation in different mRNA regions. Overall design: Examination of m6A methylation patterns after targeted methylation of Actin and targeted demethylation of Malat1.
创建时间：
2020-09-03
