KDM4B epigenetically protects against obesity and metabolic dysfunction [gene expression]

KDM4B (lysine demethylase 4B) in adipose tissues plays a critical role in energy balance, oxidation, lipolysis and thermogenesis. Loss of KDM4B in mice resulted in obesity associated with reduced energy expenditure and impaired adaptive thermogenesis. Mechanistically, we determined that KDM4B directly controls the expression of multiple metabolic genes. To explore the molecular mechanisms of Kdm4b deficiency-induced obesity, we performed a microarray analysis on the Epi, SubQ and BAT of 2-month-old WT and whole body Kdm4b KO mice