Synthesis of CF<sub>3</sub>‑Containing 3,3′-Cyclopropyl Spirooxindoles by Sequential [3 + 2] Cycloaddition/Ring Contraction of Ylideneoxindoles with 2,2,2-Trifluorodiazoethane
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资源简介：
A [3 + 2] cycloaddition/ring contraction sequence of ylideneoxindoles with in situ-generated 2,2,2-trifluorodiazoethane without the use of any transition-metal catalyst has been developed. The reaction provides efficient access to biologically important and synthetically useful CF3-containing 3,3′-cyclopropyl spirooxindoles in high yield (74–99%) with high diastereoselectivity (>95:5 d.r.).
创建时间：
2014-03-07
