“Yes” indicates the same extent of cleavage as observed in plasma without inhibitors, “partial” indicates reduced cleavage compared to uninhibited plasma, while “no” indicates that no degradation was
Parallel Artificial Membrane Permeability is an in vitro surrogate to determine the permeability of drugs across cellular membranes. PAMPA at pH 5 was experimentally determined in a dataset of 5,473 u
Emergence of drug resistant Plasmodium falciparum including artemisinin-tolerant parasites highlights the need for new antimalarials. We have previously shown that dibemequines, 4-amino-7-chloroquinol
