Cancer can be envisioned as a metabolic disease driven by pressure selection and intercellular cooperativeness. Together with anaerobic glycolysis, the Warburg effect, formally corresponding to uncoup

NIAID Data Ecosystem50

PD-1 instructs a tumor suppressive metabolic program to restrain AP-1 activity in T cell lymphoma

T细胞淋巴瘤机制

肿瘤代谢调控

To dissect T cell lymphoma pathogenesis, we previously engineered a genetically controllable murine model of human T-NHL based on tamoxifen-inducible irreversible expression of the T-NHL oncogene ITK-

NIAID Data Ecosystem30

eIF4GI Links Nutrient Sensing by mTOR to Cell Proliferation and Inhibition of Autophagy

肿瘤代谢调控

蛋白质翻译

Translation initiation factors have complex functions in cells which are not yet understood. We show that depletion of initiation factor eIF4GI only modestly reduces overall protein synthesis in cells

NIAID Data Ecosystem60

Oncogenic KRAS mediates amino acid metabolism during nutrient stress via regulation of NRF2 and ATF4 in NSCLC [shKRAS low Q]. Homo sapiens

肿瘤代谢调控

KRAS信号通路

Glutamine is a key nutrient for tumor cells that supports nucleotide and amino acid biosynthesis, replenishes the TCA cycle intermediates and contributes to redox metabolism. We identified oncogenic K

NIAID Data Ecosystem40

Combinatorial targeting of glycolysis and oxidative phosphorylation suppresses tumor growth and metastases.

资源简介：

相关数据集