SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol

SLC6A19 mediates the uptake of neutral amino acids across the plasma membrane. Uptake of an amino acid molecule is accompanied by uptake of a sodium ion. The protein is abundant in cells in the small intestine and kidney. Its deficiency is associated with Hartnup disorder, the failure to take up neutral amino acids efficiently from the gut lumen and to reabsorb them in the proximal kidney tubule (Kleta et al. 2004, Seow et al. 2004).

SLC6A19介导中性氨基酸在质膜上的摄取。氨基酸分子的摄取伴随着钠离子的摄取。该蛋白在小肠和肾脏细胞中含量丰富。其缺乏与Hartnup病相关，表现为无法从肠道腔内高效摄取中性氨基酸以及在上皮近端肾小管重吸收它们（Kleta等，2004年，Seow等，2004年）。