Data from: Gentamicin-loaded silk/nanosilver composite scaffolds for MRSA-induced chronic osteomyelitis

Methicillin-resistant staphylococcus aureus (MRSA) often induces chronic
osteomyelitis and then bone defects. Here, gentamicin-loaded
silk/nanosilver composite scaffolds were developed to treat MRSA-induced
chronic osteomyelitis. AgNO3 was reduced with silk as a reducing agent in
formic acid, forming silver nanoparticles in situ that were distributed
uniformly in the composite scaffolds. Superior antibacterial properties
against MRSA were achieved for the composite scaffolds, without the
compromise of osteogenesis capacity. Then gentamicin was loaded on the
scaffolds for better treatment of osteomyelitis. In vivo results showed
effective inhibition of the growth of MRSA bacteria, confirming the
promising future in the treatment of chronic osteomyelitis.