Crystal Structure of a Stabilized DS-SOSIP.6mut BG505 gp140 HIV-1 Env Trimer, Containing Mutations I201C-P433C (DS), L154M, Y177W, N300M, N302M, T320L, I420M in Complex with Human Antibodies PGT122 and 35O22 at 4.3 A

Protein Data Bank Japan2024-10-23 更新2026-03-21 收录

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Crystal Structure of a Stabilized DS-SOSIP.6mut BG505 gp140 HIV-1 Env Trimer, Containing Mutations I201C-P433C (DS), L154M, Y177W, N300M, N302M, T320L, I420M in Complex with Human Antibodies PGT122 and 35O22 at 4.3 A Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35022 Heavy chain, ... Authors: Pancera, M, Chuang, G.-Y, Xu, K, Kwong, P.D. Deposit date: 2017-02-14 Release date: 2017-03-29 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (3.503 Å) Cite: Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity. J. Virol., 91, 2017

携带I201C-P433C（DS）、L154M、Y177W、N300M、N302M、T320L、I420M突变的稳定化DS-SOSIP.6突变型BG505 gp140 HIV-1包膜蛋白三聚体与人抗体PGT122及35O22形成复合物的晶体结构，分辨率为4.3 Å。描述符：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1-4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、35022重链…… 作者：Pancera, M、Chuang, G.-Y、Xu, K、Kwong, P.D. 存入日期：2017-02-14 发布日期：2017-03-29 最后修改日期：2024-10-23 实验方法：X射线衍射（3.503 Å）引用文献：《基于结构设计可溶性预融合闭合型HIV-1包膜蛋白三聚体：降低CD4结合亲和力并改善免疫原性》，《病毒学杂志》，91卷，2017年

创建时间：

2017-02-14