Human hypoxanthine guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((R)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine
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Human hypoxanthine guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((R)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine Descriptor: (3-{(3R,4R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-[(2R)-2-hydroxy-2-phosphonoethoxy]pyrrolidin-1-yl}-3-oxopropy l)phosphonic acid, Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION Authors: Keough, D.T, Rejman, D, Guddat, L.W. Deposit date: 2017-11-16 Release date: 2017-12-06 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.909 Å) Cite: Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics. ACS Chem. Biol., 13, 2018
本数据集为结合有[3R,4R]-4-鸟嘌呤-9-基-3-((R)-2-羟基-2-膦酰乙基)氧基-1-N-(膦酰丙酰基)吡咯烷的人次黄嘌呤鸟嘌呤磷酸核糖转移酶（Human hypoxanthine guanine phosphoribosyltransferase）复合物。
描述符：(3-{(3R,4R)-3-(2-氨基-6-氧代-1,6-二氢-9H-嘌呤-9-基)-4-[(2R)-2-羟基-2-膦酰乙氧基]吡咯烷-1-基}-3-氧代丙基)膦酸、次黄嘌呤鸟嘌呤磷酸核糖转移酶、镁离子。
作者：Keough, D.T、Rejman, D、Guddat, L.W.
沉积日期：2017-11-16
发布日期：2017-12-06
最后修改日期：2024-03-13
实验方法：X射线衍射（分辨率1.909埃）
引用文献：《间日疟原虫次黄嘌呤鸟嘌呤磷酸核糖转移酶抑制剂作为潜在抗疟治疗药物的设计》，刊载于ACS Chem. Biol.，第13卷，2018年
创建时间：
2017-11-16
