Supplementary Material

Supplementary Table 1. The transition pattern of the 7 common uremic indicators between case and control periods before hemodialysis initiation (N = 1,079). “No” means the indicator does not reach the predefined cutoff values shown on the first column, whereas “Yes” means the opposite. The order of these indicators follows the frequency of “no-to-yes” from high to low. Supplementary Table 2. Biochemical characteristics in control and case periods (N = 1,079) Supplementary Table 3. Distribution of 30-day and daily doses of furosemide in control and case periods and based on the three dialysis timing groups. Supplementary Figure 1. Flow diagram of patient selection. Supplementary Figure 2. Case-crossover study design and timing of exposure measurements including uremic indicators and medications in relation to hemodialysis initiation.