Transcriptional analysis of adult LRH-1 knockout livers reveals a novel role for LRH-1 in hepatic lipid homeostasis and phospholipid remodeling
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https://www.ncbi.nlm.nih.gov/sra/SRP131036
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Purpose: To identify novel LRH-1 target genes in adult knockout livers. Overall design: Methods & Results: Loss of LRH-1 in adult liver resulted in hepatic steatosis. To assess the role of LRH-1 in hepatic lipid metabolism, we performed transcriptional profiling on total RNA isolated from 14-week-old adult male knockout mice fed standard diet (SD) or high-fat diet (HFD) for 6 weeks. Mice infected with AAV8-eGFP served as controls. RNA-Seq analysis revealed novel LRH-1 gene targets involved in phosphatidylcholine metabolism and phospholipid diversity.
创建时间：
2020-01-02
