Irinotecan-treated cancer patients with SNP information, genetic factor, and clinical parameters for incidence of diarrhea.

“UGT1A1*6 or *28” is a genetic factor constructed from 2 polymorphisms (UGT1A1*6 and *28); “2” indicates *6/*6, *28/*28 or *6/*28, “1” indicates *6 or *28, and “0” indicates “other than 2 and 1.” Area: body surface area (m2), PS: performance status, Cr: grade of creatinine, Hg: grade of hemoglobin, Alb: grade of albumin, ALP: grade of alkaline phosphatase, and GOT: grade of glutamic oxaloacetic transaminase. Each laboratory test value (Alb, Hg, GOT, ALP, and Cr) was recorded before the irinotecan therapy. For each type of clinical tests the grade and aberrant values were defined according to the National Cancer Institute - Common Toxicity Criteria (NCI-CTC, Version 2.0). Cmax/dose: SN38 Cmax/dose [10−3×m2/L]. AUC: area under the concentration-time curve. AUC ratio: Ratio of AUCSN38/AUCCPT-11. 5-FU: 5-fluorouracil, CDDP: cisplatin, MMC: mitomycin C, VP16: etoposide. * and † indicate pp