Differential binding of PARP-1 domains (AW-YFP ChIP-seq). Differential binding of PARP-1 domains (AW-YFP ChIP-seq)

We interrogated the differential binding of PARP-1 domains (ZnI, ZnII, AD-WGR) and a ZnI mutant in Drosophila via ChIP-seq of third-instar larvae. Overall design: We performed ChIP-seq using third-instar larvae expressing AW-YFP (Automodification and WGR domains) and Control animals (3 biological replicates per group).