Crystal structure of MerTK kinase domain in complex with LDC1267
收藏Protein Data Bank Japan2024-01-31 更新2026-03-21 收录
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Crystal structure of MerTK kinase domain in complex with LDC1267 Descriptor: CHLORIDE ION, Tyrosine-protein kinase Mer, ~{N}-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluoranyl-phenyl]-4-ethoxy-1-(4-fluoranyl-2-methyl-phenyl)pyrazole-3-carboxamide Authors: Schimpl, M, Pflug, A, McCoull, W, Nissink, J.W.M, Overman, R.C, Rawlins, P.B, Truman, C, Underwood, E, Warwicker, J, Winter-Holt, J. Deposit date: 2020-09-05 Release date: 2020-10-28 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.762 Å) Cite: A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding. Biochem.J., 477, 2020
创建时间：
2020-09-05
