Power Estimates () for two-sided tests, testing for the presence of risk or protective variants, when there is a mixture of risk and protective variants in the region of interest.

In addition to risk variants in the region, there are between protective variants as well. Simulation model corresponds to one of the two scenarios: neutral variants (1), and mildly deleterious variants (2). The total sample size is cases and controls. Collapsing (C) vs. weighted-Sum (WS) vs. replication-based (R).