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IntroductionGood hand hygiene compliance among healthcare workers is crucial for preventing healthcare-associated infections. While an extensive amount of research has focused on barriers to compliance with hand hygiene guidelines, there remains a critical gap in understanding the factors contributing to consistently excellent compliance among some individuals. Thus, the main aim of this study is to learn from these "champions" of hand hygiene and identify facilitating factors that enable and sustain high compliance using the Theoretical Domains Framework (TDF).MethodsIn this qualitative study, we conducted problem-oriented semi-structured interviews with questions based on the 14 domains of the revised TDF. The N = 25 participants included physicians and nurses from three German hospitals. They were selected based on a reported history of excellent hand hygiene compliance.ResultsAll topics discussed by the interviewees could be categorised into the 14 TDF domains. Five TDF domains were particularly prominent: environmental context and resources, behavioural regulation, knowledge, social influences, and skills. The single most important facilitator for good hand hygiene compliance among both physicians and nurses was the construct/code goals (i.e., patient protection and self-protection). Additionally, for physicians, developing hand hygiene as a habit was considered particularly advantageous. Conversely, nurses emphasised that learning correct hand hygiene during their vocational training was especially beneficial for good compliance.ConclusionsThe results highlight the importance of clear goals, habit development, comprehensive training, adequate resources, and a positive culture of communication in promoting good hand hygiene practices. The TDF has been proven to be a suitable model for identifying facilitating factors for hand hygiene compliance among healthcare workers.