The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988569

The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988569 Descriptor: 2-(2,6-difluorophenyl)-5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... Authors: Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. Deposit date: 2021-05-13 Release date: 2022-05-18 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.38 Å) Cite: Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023

野生型PA核酸内切酶（2009/H1N1/加利福尼亚株）与SJ000988569形成的复合物晶体结构，SJ000988569的结构式描述为：2-(2,6-二氟苯基)-5-羟基-N-[2-(2-甲氧基吡啶-4-基)乙基]-6-氧代-3,6-二氢嘧啶-4-甲酰胺，体系包含六乙烯基吡咯烷酮K15、锰(II)离子…… 作者：Cuypers M.G.、Slavish J.P.、Rankovic Z.、White S.W.。存储日期：2021-05-13；发布日期：2022-05-18；最后修改日期：2023-10-25。实验方法：X射线衍射（分辨率2.38埃）。引用文献：《化学骨架再利用：基于结构导向策略将HIV整合酶抑制剂转化为强效流感病毒RNA依赖RNA聚合酶抑制剂，以最大限度降低耐药潜力》，《欧洲医药化学杂志》，247卷，2023年。