Comparison of automatically generated results provided by the package before/after flagging outliers for the Subtract background method for the simulated analytes.

In Analyte 1 no outliers and no missing values were included, in Analyte 2 seven missing values were included, in Analyte 3 one outlier and seven missing values were included and in Analyte 4 two outliers were included in the original simulated data. Only in Analyte 4 outliers were flagged by the package and their removal changed results. For Analyte 4, the limits of quantification for the coefficient of variation method could not be estimated with all data due to the fact that the minimum coefficient of variation value was larger than the specified 30% cutoff.