Supporting data for "Ewastools: Infinium Human Methylation BeadChip pipeline for population epigenetics integrated into Galaxy"

Infinium Human Methylation BeadChip is an array platform for complex evaluation of DNA methylation at an individual CpG loci in the human genome based on Illuminas bead technology and it is one of the most common techniques used in epigenome-wide association studies (EWAS). Finding associations between epigenetic variation and phenotype is a significant challenge in biomedical research. The newest version, HumanMethylationEPIC, quantifies the DNA methylation level of 850k CpG sites, while the previous versions, HumanMethylation450 and HumanMethylation27, measured over 450k and 27k loci, respectively. Although a number of bioinformatics tools have been developed to analyse this assay, they require some programming skills and experience in order to be usable.<br> We have developed a pipeline for the Galaxy platform for those without experience aimed at DNA methylation analysis using the Infinium Human Methylation BeadChip. Our tool is integrated into Galaxy, a web based platform. This allows users to analyse data from the Infinium Human Methylation BeadChip in the easiest possible way. <br>The pipeline provides a group of integrated analytical methods wrapped into an easy to use interface. Our tool is available from the Galaxy toolshed, GitHub repository and also as a Docker image. The aim of this project is to make Infinium Human Methylation BeadChip analysis more flexible and accessible to everyone.