TNA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G

TNA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G Descriptor: 2-azanyl-9-[(2~{R},3~{R},4~{S})-3-oxidanyl-4-[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxy-oxolan-2-yl]-1~{H}-purin-6-one, 4-AMINO-1-[(1S,3R,4R,7S)-7-HYDROXY-1-(HYDROXYMETHYL)-2,5-DIOXABICYCLO[2.2.1]HEPT-3-YL]-5-METHYLPYRIMIDIN-2(1H)-ONE, DIGUANOSINE-5'-TRIPHOSPHATE, ... Authors: Fang, Z, Giurgiu, C, Szostak, J.W. Deposit date: 2021-02-07 Release date: 2021-09-08 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure-Activity Relationships in Nonenzymatic Template-Directed RNA Synthesis. Angew.Chem.Int.Ed.Engl., 60, 2021

与鸟苷二核苷酸配体G(5')ppp(5')G结合的RNA引物复合物的3'端硫代苏糖核酸（TNA）修饰
描述：2-氨基-9-[(2R,3R,4S)-3-羟基-4-[羟基-二(氧代)-λ⁶-膦酰基]氧基-四氢呋喃-2-基]-1H-嘌呤-6-酮、4-氨基-1-[(1S,3R,4R,7S)-7-羟基-1-(羟甲基)-2,5-二氧杂双环[2.2.1]庚-3-基]-5-甲基嘧啶-2(1H)-酮、二鸟苷-5'-三磷酸……
作者：Fang, Z、Giurgiu, C、Szostak, J.W.
提交日期：2021-02-07
发布日期：2021-09-08
最后修改日期：2023-10-18
实验方法：X射线衍射（2.2 Å）
引用文献：《非酶促模板指导RNA合成中的构效关系》，Angew.Chem.Int.Ed.Engl., 60, 2021