The effect and mechanism of freeze-dried powder of Poecilobdella manillensis on improving inflammatory injury of rat glomerular mesangial cells through TXNIP / NLRP3 pathway.

In this study, transcriptome technology was used to explore the mechanism of Poecilobdella manillensis lyophilized powder to improve the inflammatory injury of rat mesangial cells.In general, this study found that TXNIP / NLRP3 signaling pathway is one of the effective mechanisms of Poecilobdella manillensis lyophilized powder to improve the inflammatory injury of diabetic nephropathy. Overall design: The cell samples were HBZY-1 rat mesangial cells, which were divided into three groups : control group, LPS-induced model group and high-dose water extract of Poecilobdella manillensis lyophilized powder group for transcriptome sequencing, with three biological replicates in each group.