A Single-Cell Transcriptomic Atlas of Artery Aging in Cynomolgus Monkey

Aging is one of the major risk factors for cardiovascular diseases; however, our understanding of how aging affects the cellular and molecular components of vasculatures and contributes to cardiovascular diseases is still limited. Compared with other model organisms, monkeys are more similar to humans in terms of their genetic, anatomical and physiological features, thus representing an ideal model for studying vascular aging and its effect on diseases. Here, we report a single-cell transcriptomic survey of aortic and coronary arteries from eight young and eight old cynomolgus monkeys.