Antiphospholipid antibodies induce Proinflammatory and Procoagulant Pathways in Endothelial cells.

Antiphospholipid syndrome (APS) is an autoimmune thrombophillia characterized by recurrent thrombotic events and/or pregnancy morbidity in the presence of antiphospholipid antibodies detected either as anti-cardiolipin, anti-ß2 Glycoprotein I (anti-ß2GPI) or Lupus anticoagulant (LA). Endothelial deregulation characterizes the syndrome. To address the gene expression changes occurring in the endothelial cells in the context of APS, we performed transcriptome analysis of Human Umbilical Vein Endothelial cells (HUVECs) stimulated with anti-ß2GPI-ß2GPI complexes. Overall design: RNA-seq analysis in naive and induced Huvec cells