Zhang2009 - Genome-scale metabolic network of Thermotoga maritima

Zhang2009 - Genome-scale metabolic network of
Thermotoga maritima

This model is described in the article:

Three-dimensional structural
view of the central metabolic network of Thermotoga
maritima.

Zhang Y, Thiele I, Weekes D, Li Z,
Jaroszewski L, Ginalski K, Deacon AM, Wooley J, Lesley SA, Wilson
IA, Palsson B, Osterman A, Godzik A.
Science 2009 Sep; 325(5947):
1544-1549
Abstract:

Metabolic pathways have traditionally been described in
terms of biochemical reactions and metabolites. With the use of
structural genomics and systems biology, we generated a
three-dimensional reconstruction of the central metabolic
network of the bacterium Thermotoga maritima. The network
encompassed 478 proteins, of which 120 were determined by
experiment and 358 were modeled. Structural analysis revealed
that proteins forming the network are dominated by a small
number (only 182) of basic shapes (folds) performing diverse
but mostly related functions. Most of these folds are already
present in the essential core (approximately 30%) of the
network, and its expansion by nonessential proteins is achieved
with relatively few additional folds. Thus, integration of
structural data with networks analysis generates insight into
the function, mechanism, and evolution of biological
networks.

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