Crystal structure of TrkA in complex with PF-05206283
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Crystal structure of TrkA in complex with PF-05206283 Descriptor: High affinity nerve growth factor receptor, N-{5-[4-amino-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}-2-(4-chlorophenyl)acetamide Authors: Jayasankar, J, Kurumbail, R, Brown, D, Skerratt, S. Deposit date: 2016-04-19 Release date: 2017-03-01 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.59 Å) Cite: The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain. J. Med. Chem., 59, 2016
与PF-05206283结合的TrkA晶体结构 描述：TrkA为高亲和力神经生长因子受体，结合配体为N-{5-[4-氨基-7-异丙基-7H-吡咯并[2,3-d]嘧啶-5-羰基]吡啶-3-基}-2-(4-氯苯基)乙酰胺 作者：Jayasankar J、Kurumbail R、Brown D、Skerratt S 入库日期：2016-04-19 发布日期：2017-03-01 最后更新日期：2024-03-06 测试方法：X射线衍射（分辨率1.59 Å） 引用文献：《用于疼痛治疗的强效、选择性且外周受限的泛Trk抑制剂（PF-06273340）的发现》，《药物化学杂志》（J. Med. Chem.），59卷，2016年
