Novel hydroxyl tricyclics (e.g. GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

Novel hydroxyl tricyclics (e.g. GSK966587) as potent inhibitors of bacterial type IIA topoisomerases Descriptor: (S)-4-((4-(((2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methyl)amino)piperidin-1-yl)methyl)-3-fluoro-4-hydroxy-4H-pyrrolo[3,2,1-de][1,5]naphthyridin-7(5H)-one, 5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*AP*CP*AP*CP *CP*GP*CP*AP*C)-3', 5'-D(*TP*GP*TP*GP*CP*GP*GP*TP*GP*TP*AP*CP*CP*TP *AP*CP*GP*GP*CP*T)-3', ... Authors: Miles, T.J, Hennessy, A.J, Bax, B, Brooks, G, Brown, B.S, Brown, P, Cailleau, N, Chen, D, Dabbs, S, Davies, D.T, Esken, J.M, Giordano, I, Hoover, J.L, Huang, J, Jones, G.E, Sukmar, S.K.K, Spitzfaden, C, Markwell, R.E, Minthorn, E.A, Rittenhouse, S, Gwynn, M.N, Pearson, N.D. Deposit date: 2013-06-20 Release date: 2013-08-07 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Novel Hydroxyl Tricyclics (E.G., Gsk966587) as Potent Inhibitors of Bacterial Type Iia Topoisomerases. Bioorg.Med.Chem.Lett., 23, 2013

数据集主题：新型羟基三环类化合物（如GSK966587）作为强效细菌IIA型拓扑异构酶抑制剂
描述项：(S)-4-((4-(((2,3-二氢-[1,4]二噁英[2,3-c]吡啶-7-基)甲基)氨基)哌啶-1-基)甲基)-3-氟-4-羟基-4H-吡咯并[3,2,1-de][1,5]萘啶-7(5H)-酮、5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*AP*CP*AP*CP*CP*GP*CP*AP*C)-3'、5'-D(*TP*GP*TP*GP*CP*GP*GP*TP*GP*TP*AP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3' 等
作者：Miles, T.J.、Hennessy, A.J.、Bax, B、Brooks, G、Brown, B.S、Brown, P、Cailleau, N、Chen, D、Dabbs, S、Davies, D.T、Esken, J.M、Giordano, I、Hoover, J.L、Huang, J、Jones, G.E、Sukmar, S.K.K、Spitzfaden, C、Markwell, R.E、Minthorn, E.A、Rittenhouse, S、Gwynn, M.N、Pearson, N.D.
提交日期：2013年6月20日
发布日期：2013年8月7日
最后修改日期：2023年12月20日
检测方法：X射线衍射（分辨率2.6 Å）
引用文献：《新型羟基三环类化合物（如GSK966587）作为强效细菌IIA型拓扑异构酶抑制剂》，Bioorg.Med.Chem.Lett., 23, 2013