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Enantioselective Synthesis of Highly Substituted Chromans via the Oxa-Michael–Michael Cascade Reaction with a Bifunctional Organocatalyst

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NIAID Data Ecosystem2026-03-09 收录
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https://figshare.com/articles/dataset/Enantioselective_Synthesis_of_Highly_Substituted_Chromans_via_the_Oxa_Michael_Michael_Cascade_Reaction_with_a_Bifunctional_Organocatalyst/2111839
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A highly enantioselective synthesis of chiral chroman derivatives via an oxa-Michael–Michael cascade reaction has been developed using a bifunctional thiourea organocatalyst. The products were obtained with excellent enantioselectivities (up to >99%), good yields (up to 95%), and diastereoselectivities (up to 5:1).
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2016-02-12
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