Human GKRP bound to AMG-3227 and S6P

Human GKRP bound to AMG-3227 and S6P Descriptor: 4-[(2S)-4-[(6-aminopyridin-3-yl)sulfonyl]-2-(prop-1-yn-1-yl)piperazin-1-yl]-N-methylbenzenesulfonamide, D-SORBITOL-6-PHOSPHATE, GLYCEROL, ... Authors: Jordan, S.R, Chmait, S. Deposit date: 2014-01-17 Release date: 2014-07-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series. J.Med.Chem., 57, 2014结合AMG-3227与S6P的人类GKRP（Glucokinase Regulatory Protein，葡萄糖激酶调节蛋白）数据集描述：4-[(2S)-4-[(6-氨基吡啶-3-基)磺酰基]-2-(丙-1-炔-1-基)哌嗪-1-基]-N-甲基苯磺酰胺、D-山梨醇-6-磷酸、甘油等。作者：Jordan, S.R、Chmait, S. 存入日期：2014-01-17 发布日期：2014-07-30 最后修改日期：2023-09-20 实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.4埃）。引用文献：葡萄糖激酶-葡萄糖激酶调节蛋白相互作用的小分子干扰剂：3. N-芳基磺酰胺基-N'-芳基哌嗪系列芳基甲醇区域的构效关系。《药物化学杂志》（J.Med.Chem.），57卷，2014年