Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 1,1-Dimethylethyl {(3R,6S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-3-piperidinyl}carbamate

Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 1,1-Dimethylethyl {(3R,6S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-3-piperidinyl}carbamate Descriptor: 3-phosphoinositide-dependent protein kinase 1, GLYCEROL, SULFATE ION, ... Authors: Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M. Deposit date: 2011-01-17 Release date: 2011-03-09 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011

结合1,1-二甲基乙基{(3R,6S)-1-[2-氨基-6-(3-氨基-1H-吲唑-6-基)-4-嘧啶基]-6-甲基-3-哌啶基}氨基甲酸酯的磷酸肌醇依赖性蛋白激酶1（Phosphoinositide-Dependent Kinase-1，PDK1）激酶结构域。
数据集描述：3-磷酸肌醇依赖性蛋白激酶1、甘油、硫酸根离子……
作者：Medina, J.R.、Becker, C.J.、Blackledge, C.W.、Duquenne, C.、Feng, Y.、Grant, S.W.、Heerding, D.、Li, W.H.、Miller, W.H.、Romeril, S.P.、Scherzer, D.、Shu, A.、Bobko, M.A.、Chadderton, A.R.、Dumble, M.、Gradiner, C.M.、Gilbert, S.、Liu, Q.、Rabindran, S.K.、Sudakin, V.、Xiang, H.、Brady, P.G.、Campobasso, N.、Ward, P.、Axten, J.M.。
存放日期：2011-01-17
发布日期：2011-03-09
最后修改日期：2024-10-30
测试方法：X射线衍射（分辨率2埃）
引用文献：《基于结构设计的强效选择性3-磷酸肌醇依赖性蛋白激酶1（PDK1）抑制剂》，《Journal of Medicinal Chemistry》，54卷，2011年。