macroH2A2 overexpression in head and neck squamous cell carcinoma cell line T-HEp3.

We report the RNA expression profile in the restoration of macroH2A2 in tumorigenic (T-HEp3) HNSCC cell line. T-HEp3 is a human epidermoid carcinoma, which grows on chorioallantoic membreane and metastasizes with high efficency into the organs of chick embryo. Upon serial paasage for more than 50 times in vitro , T-HEp3 loses tumorigenic and metastatic potential and termed as dormant D-HEp3. This is an ideal cell line model system to study cancer dormancy. RNA sequencing was performed in T-HEp3 cell line with control (H2B-GFP expression) or with macroH2A2 overexpression.