Crystal Structure of Human Beta Secretase Complexed with inhibitor
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Crystal Structure of Human Beta Secretase Complexed with inhibitor Descriptor: Beta-secretase 1, N-[(1S,2S)-2-AMINO-1-(3-THIENYLMETHYL)HEXYL]-2-({[(1S,2S)-2-METHYLCYCLOPROPYL]METHYL}AMINO)-6-[METHYL(METHYLSULFONYL)AMINO]ISONICOTINAMIDE Authors: Munshi, S. Deposit date: 2006-12-15 Release date: 2007-08-14 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation. Bioorg.Med.Chem.Lett., 17, 2007
创建时间:
2006-12-15



