It is generally assumed that recurrent mutations within a given cancer driver gene elicit similar drug responses. Recently, cancer genome studies have delineated recurrent but divergent missense mutat
RHOA is a recurrently mutated gene in diffuse-type gastric cancer, whose molecular influence in gastric cancer has not been well uncovered. We aimed to clarify the contribution of RHOA to pro-oncogene
The goal of this study is to determine the impact of ALK inhibition or phospho-deficient mutation of CDK9 on gene expresion profiles in ovarian cancer cells We performed bulk RNA sequencing on three c
FGFR2 activation by FGF2 stimulation and FGFR2 fusion mutations or FGFR2 inhibition by Pemigatinib stimulation in cholangiocarcinoma cell lines, followed by detection of changes in WDR5 binding protei
Genomic amplification of 19q12 occurs in several cancer types including ovarian cancer where it is associated with primary treatment failure. We systematically attenuated expression of genes within th
