Intra- and inter-modular effects of mutations.

The first row corresponds to the normalized phenotypic effect of a genetic mutation on its own module; the second row corresponds to the normalized phenotypic effect of a genetic mutation within a module on the other modules (pleiotropy). The median±SE are presented for FG and MVG, p-value is as obtained from Wilcoxon rank sum test for equal medians. The range of effects in solution space was obtained by measuring the effects over a large random sample of genomes that solve G1 (see Text S1 section 3).